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-synuclein, that's a main part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which is an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) stress, suggest that dysfunction on the intracellular proteinase devices, for instance ubiquitin-proteasome program or lysosomal process, which eliminates pointless harmful proteins i
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